cf article de Nee 2000 (Phil.Trans.R.Soc) : “The quantitative model of the evolution of coviruses discussed in Nee & Maynard Smith (19 9 0) is peculiar and seems to have in mind some sort of well- mixed cell culture as the environment in which evolution is occurring. In p articular, it is comp letely lack ing any epidemiology, which is a curious feature for a model of virus evolution.”