du point de vue des lignées non-symptomatiques, il est probable qu'on observe des mutations sur le gène VI, dans la mesure où : « the chlorosis and stunting in P6-transgenic and CaMV-infected plants are dependent on interactions between P6 and components involved in ethylene signalling, and that the suppressor gene product may function to augment these interactions. » Geri et al. 2004. Plant Mol Biol

Pooggin et al. (1998) concluded that mutations occurred within the 35S RNA leader sequence at “a surprisingly low frequency.” The requirement for a functional ribosome shunt could provide one constraint that could limit change within the 35S RNA leader sequence (Shababi et al. 2006).